Ligand id: 592

Name: telmisartan

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: telmisartan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 72.94
Molecular weight 514.24
XLogP 9.77
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension and diabetic nephropathy in hypertensive patients with type 2 diabetes.
Mechanism Of Action and Pharmacodynamic Effects
Binds reversibly and selectively to the AT1 receptor in vascular smooth muscle and adrenal gland, thus preventing the vasocontrictive effects of angiotensin II and resulting in a decrease in systematic vascular resistance.
External links