chenodeoxycholic acid

Ligand id: 608

Name: chenodeoxycholic acid

Abbreviated name: CDCA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 77.76
Molecular weight 392.29
XLogP 6.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat certain types of gall stones in patients where surgery is not an option.
Mechanism Of Action and Pharmacodynamic Effects
May directly influence synthesis and transport of bile acids via interaction with the bile acid receptor, FXR (farnesoid X receptor). The net effect of chenodeoxycholic acid is to reduce cholesterol and cholic acid synthesis in the liver thus reducing the biliary load of stone forming compounds.