auranofin

Ligand id: 6306

Name: auranofin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 0
Rotatable bonds 15
Topological polar surface area 139.73
Molecular weight 678.13
XLogP 2.93
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Auranofin is a gold-containing medicine used for the management of rheumatoid arthritis in patients who do not respond to or are intolerant of other medicines.
Mechanism Of Action and Pharmacodynamic Effects
Drug treatment decreases levels of rheumatoid factors and immunoglobulins, potentially via inhibition of the selenoenzyme, thioredoxin reductase [1] which has been shown to suppress the pro-inflammatory NLRP3/interleukin-1β pathway.
External links