Ligand id: 6319

Name: alogliptin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 93.67
Molecular weight 339.17
XLogP 1.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Alogliptin is an oral medication for the treatment of type 2 diabetes. Clinical formulations contain alogliptin benzoate (PubChem CID 16088021).
Mechanism Of Action and Pharmacodynamic Effects
Alogliptin inhibits dipeptidyl peptidase IV (DPP4). Inhibition of this enzyme increases levels of glucagon like peptide 1. This in turn, inhibits glucagon production from pancreatic α-cells and increases production of insulin from pancreatic β-cells.
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