Ligand id: 6344

Name: ramiprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 106.94
Molecular weight 388.2
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Prodrug ramipril is used in the management of mild to severe hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Competes with the binding of angiotensin I to angiotensin-converting enzyme therefore reducing conversion of angiotensin I to angiotensin II. Decreased levels of angiotensin II result in a decrease in blood pressure.