quinapril

Ligand id: 6350

Name: quinapril

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 95.94
Molecular weight 438.22
XLogP 6.38
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension and as an adjunct therapy in the treatment of congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Quinapril is converted to active metabolite quinaprilat. Quinaprilat is an ACE inhibitor which Inhibits the conversion of angiotensin I to angiotensin II, which in turn decreases blood pressure. Also causes an increase in plasma renin activity. As a prodrug this compound is unlikely to have significant ACE inhibitory activity. Therefore we have not tagged a primary target for this compound.
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