Ligand id: 6352

Name: quinaprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 106.94
Molecular weight 410.18
XLogP 5.64
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Prodrug quinapril is used in the treatment of hypertension and as an adjunct therapy in the treatment of congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
From the prodrug quinapril. Inhibits the conversion of angiotensin I to angiotensin II, which in turn decreases blood pressure. Also causes an increase in plasma renin activity.