perindoprilat

Ligand id: 6373

Name: perindoprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 106.94
Molecular weight 340.2
XLogP 1.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Produg perindopril is an ACE inhibitor used to treat hypertension, congestive heart failure, post-myocardial infarction and coronary disease.
Mechanism Of Action and Pharmacodynamic Effects
Metabolite of the prodrug perindopril. Inhibits the conversion of angiotensin I to angiotensin II, which in turn decreases blood pressure. Also causes an increase in plasma renin activity.