Ligand id: 6375

Name: benazeprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 106.94
Molecular weight 396.17
XLogP 5.53
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension, alone or in combination with thiazide diuretics.
Mechanism Of Action and Pharmacodynamic Effects
Benazeprilat competes with angiotensin I for binding to the angiotensin-converting enzyme and inhibits the conversion of angiotensin I to angiotensin II. Decreased concentrations of angiotensin II result in a lowering of blood pressure.