Ligand id: 6378

Name: imidaprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 127.25
Molecular weight 377.16
XLogP 2.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The prodrug is administered to treat hypertension and congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Imidaprilat competes with angiotensisn I for binding to ACE thereby inhibiting its enzymatic conversion to angiotensin II. Reduced levels of angiotensin II leads to reduced blood pressure by modifying the renin-angiotensin system (RAS).