dabigatran etexilate

Ligand id: 6379

Name: dabigatran etexilate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 2
Rotatable bonds 19
Topological polar surface area 154.03
Molecular weight 627.32
XLogP 6.36
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dabigatran is a thrombin inhibitor used to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation and may be used post-operatively (esp following orthopedic surgery). Because the antithrombotic effects of dabigatran are more predictable than those of warfarin, regular blood testing to monitor clotting level is not required.
Mechanism Of Action and Pharmacodynamic Effects
The active drug, dabigatran, is a synthetic, competitive and reversible thrombin inhibitor which disrupts the coagulation cascade and inhibits the formation of blood clots.