Ligand id: 6385

Name: argatroban

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 5
Rotatable bonds 10
Topological polar surface area 188.59
Molecular weight 508.25
XLogP -0.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Argatroban is a thrombin inhibitor for prophylaxis or treatment of thrombosis in patients with, or at risk of, heparin-induced thrombocytopenia (HIT)
Mechanism Of Action and Pharmacodynamic Effects
As a thrombin inhibitor, treatment with argatroban disrupts the coagulation cascade and inhibits the formation of blood clots.