Ligand id: 6441

Name: sivelestat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 147.25
Molecular weight 434.11
XLogP 3.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Elastase inhibitor approved in Japan and South Korea for acute lung injury.
Mechanism Of Action and Pharmacodynamic Effects
Inhibitor of human neutrophil elastase.