zofenoprilat

Ligand id: 6463

Name: zofenoprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 121.71
Molecular weight 325.08
XLogP 3.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Active form of the prodrug zofenopril which is used in the treatment of hypertension and coronary heart disease.
Mechanism Of Action and Pharmacodynamic Effects
Angiotensin coverting enzyme inhibitor. Zofenoprilat competes with angiotensisn I for binding to ACE thereby inhibiting its enzymatic conversion to angiotensin II. Reduced levels of angiotensin II leads to reduced blood pressure. However, we have been unable to find molecular data for this drug at the human target, to substantiate its MMOA.