doxycycline

Ligand id: 6464

Name: doxycycline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 2
Topological polar surface area 181.62
Molecular weight 444.15
XLogP 0.43
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat a wide range of bacterial infections, such as acne, urinary tract infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum disease), and lesions caused by rosacea. Some forms of doxycycline (e.g. doxycycline hyclate) are used to prevent malaria [3] (particularly useful in areas where chloroquine or multidrug-resistant P. falciparum are found), to treat anthrax, or to treat infections resulting from by mite, tick, or lice infestations.
Mechanism Of Action and Pharmacodynamic Effects
Antibacterial MMOA is reversible binding to the 30S ribosomal subunits to block binding of aminoacyl tRNA to mRNA and thereby inhibit bacterial protein synthesis. Human MMOA is pan-MMP inhibition but some specificity for MMP7and MMP8 is evident, and is associated with reducing inflammation and elevated levels of proinflammatory cytokines.
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