doxycycline

Ligand id: 6464

Name: doxycycline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 2
Topological polar surface area 181.62
Molecular weight 444.15
XLogP 0.43
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Periodontitis (oral cavity). Also for reducing inflammation and proinflammatory cytokines within chronic wounds.
Mechanism Of Action and Pharmacodynamic Effects
Antibacterial MMOA is reversible binding to the 30 S ribosomal subunits to block binding of aminoacyl tRNA to mRNA and thereby inhibit bacterial protein synthesis. Human MMOA is pan-MMP inhibition but some specificity for MMP7 and MMP8 to reducing inflammation and elevated levels of proinflammatory cytokines.