moexiprilat

Ligand id: 6572

Name: moexiprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 125.4
Molecular weight 470.21
XLogP 4.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The approved drug moexipril is administered for the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects
An inhibitor of angiotensin-converting enzyme. This inhibition prevents the conversion of angiotensin I to angiotensin II, thereby reducing the vasoconstriction and aldosterone secretion stimulated by angiotensin II. Also causes increased plasma renin activity. However, we have been unable to find molecular data for this drug at the human target, to substantiate its MMOA.