6-aminocaproic acid

Ligand id: 6574

Name: 6-aminocaproic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 63.32
Molecular weight 131.09
XLogP 0.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is used to reduce fibrinolysis in order to control hemorrhage and other coagulation disorders.
Mechanism Of Action and Pharmacodynamic Effects
The inhibition of fibrinolysis by aminocaproic acid appears to be principally due to inhibition of plasminogen activators. Aminocaproic acid binds reversibly to the kringle domain of plasminogen, blocking binding of plasminogen to fibrin and its activation to plasmin [1].