Ligand id: 6636

Name: clorgiline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 12.47
Molecular weight 271.05
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Clorgiline is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) [1]. MAO-A catalyses the oxidation of serotonin, dopamine and noradrenaline, so has been a major focus of drug discovery to identify compounds with potential to treat depressive illness, anxiety disorder and movement disorders such as parkinsonism.