abiraterone

Ligand id: 6745

Name: abiraterone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 33.12
Molecular weight 349.24
XLogP 5.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Abiraterone inhibits the steroidal enzyme CYP17A1 which catalyzes the biosynthesis of androgen by converting 17-hydroxyprognenolone to dehydroepiandrosterone. By inhibiting the enzyme, the drug reduces serum levels of testosterone and other androgens. This action causes shrinkage of androgen-sensitive prostate tumours.
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