Ligand id: 6807

Name: diclofenamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 137.08
Molecular weight 303.91
XLogP -0.84
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Diclofenamide was originally approved for the treatment of glaucoma [1], but use for this indication was subsequently discontinued. In August 2015, the US FDA granted marketing approval for the treatment of primary hyperkalemic and hypokalemic periodic paralysis. These conditions are two of the more common periodic paralyses, which are a group of rare hereditary disorders that cause episodes of muscle weakness or paralysis.