ezetimibe

Ligand id: 6816

Name: ezetimibe

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 60.77
Molecular weight 409.15
XLogP 5.26
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to lower cholesterol levels
Mechanism Of Action and Pharmacodynamic Effects
An anti-hyperlipidemic medication; appears to bind to the Niemann-Pick C1-Like 1 protein (NPC1L1, a critical mediator of cholesterol absorption) on gastrointestinal tract epithelial cells and in hepatocytes
Pharmacokinetics
Population pharmacokinetics
It has been reported that polymorphisms of the hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of ezetimibe (in healthy subjects given a single dose) [2]