Ligand id: 6824

Name: ixabepilone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 140.29
Molecular weight 506.28
XLogP 2.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A chemotherapeutic medication for cancer: aggressive metastatic or locally advanced breast cancer no longer responding to currently available chemotherapies. Approval refused by EMA (2008).
Mechanism Of Action and Pharmacodynamic Effects
Binds to β-tubulins (e.g. β-III tubulin) stabilising microtubules and preventing cell division.