Ligand id: 6834

Name: nitisinone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 94.35
Molecular weight 329.05
XLogP 2.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hereditary tyrosinemia type 1, in combination with controlled dietary intake of tyrosine and phenylalanine. In the EU the EMA has granted orphan disease designation for this drug for alkaptonuria and tyrosinaemia type 1 .
Mechanism Of Action and Pharmacodynamic Effects
A synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase
External links