phenprocoumon

Ligand id: 6839

Name: phenprocoumon

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 46.53
Molecular weight 280.11
XLogP 6.74
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for the prevention and treatment of thromboembolic disease; venous thrombosis, thromboembolism, pulmonary embolism and prevention of ischemic stroke in patients with atrial fibrillation. Marketing of this drug in the US has been discontinued. Individual national approval agencies may continue to grant marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Coumarin derivative that acts as a long acting oral anticoagulant, acting to deplete the reduced form of vitamin K essential to the clotting process