Ligand id: 6843

Name: teniposide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 189.07
Molecular weight 656.16
XLogP 1.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat refractory acute lymphoblastic leukemia, predominantly in children.
Mechanism Of Action and Pharmacodynamic Effects
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Forms a complex with topoisomerase II and DNA thereby inhibiting DNA synthesis and leading to cell death by preventing cells form undergoing mitosis.
External links