thioguanine

Ligand id: 6845

Name: thioguanine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 0
Topological polar surface area 110.85
Molecular weight 168.03
XLogP -0.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Initially used as a cytostatic agent in the treatment of acute lymphoblasic leukemia, but is more recently being used to treat ulcerative colitis (UC, a form of inflammatory bowel disease) [2], and some autoimmune diseases.
Mechanism Of Action and Pharmacodynamic Effects
Antineoplastic/antimetabolite compound with many possible actions, the over-arching consequence of which is to impede the use and synthesis of the purine nucleotides. This drug is an analogue of guanine and interferes with nucleic acid biosynthesis.
External links