Ligand id: 6849

Name: topiramate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 123.92
Molecular weight 339.1
XLogP -1.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat epilepsy in adults and children (also used to treat Lennox-Gastaut syndrome). Now used to prevent migraine. A combination product containing phentermine + extended-release topiramate may be used for the management of obesity (refused approval for this use by EMA, May 2013). Two recent small randomized, placebo-controlled pilot studies suggest that the GABA potentiating action of topiramate may be harnessed as treatments to help reduce alcohol intake in problem drinkers [1], and as a smoking cessation aid [3].
Mechanism Of Action and Pharmacodynamic Effects
An anticonvulsant drug; enhances GABA-activated chloride channels and inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors.
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