Ligand id: 6852

Name: vorinostat

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 78.43
Molecular weight 264.15
XLogP 2.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in cutaneous T-cell lymphoma to treat cutaneous manifestations in patients with progressive, persistent or recurrent disease.
Mechanism Of Action and Pharmacodynamic Effects
It is postulated that the antineoplastic activity of this compound arises from its inhibition of histone deacetylases, causing an accumulation of acetylated histones and thereby inducing cell cycle arrest and/or apoptosis of some transformed cells.
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