warfarin

Ligand id: 6853

Name: warfarin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: warfarin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 63.6
Molecular weight 308.1
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of pulmonary embolism, cerebral embolism, cardiomyopathy, retinal vascular occusion, atrial fibrilation and flutter, transient cerebral ischaemia, arterial embolism and thrombosis.
Mechanism Of Action and Pharmacodynamic Effects
An anticoagulant drug which acts to inhibit vitamin-K dependent synthesis of biologically active forms of various clotting factors and regulatory factors. This is achieved by inhibition of vitamin K epoxide reductase complex subunit 1 isoform 1 (VKORC1).
External links