ecallantide

Ligand id: 6955

Name: ecallantide

No information available.
Summary of Clinical Use
Ecallantide is used to treat adults who suffer attacks of hereditary angioedema (HAE, an immune system disorder) [1]. The drug acts to suppress the tissue swelling associated with hereditary angioedema. As of April 2014, children 12 years and older may be given this drug to treat HAE attacks.
Mechanism Of Action and Pharmacodynamic Effects
In hereditary angioedema kallikrein (an enzyme that increases bradykikin levels) is overactive and this leads to fluid leakage from blood vessels and associated oedema. By inhibiting the enzymatic activity of kallikrein, ecallantide reduces this tissue swelling.