Ligand id: 7007

Name: entinostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 106.34
Molecular weight 376.15
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Entinostat is being evaluated in a Phase II clinical trial alongside azacitidine (which has an epigenetic priming effect [3]) prior to check-point immunotherapy with nivolumab in patients with recurrent metastatic non-small cell lung cancer- see NCT01928576.