Ligand id: 7016

Name: BRD4770

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 73.22
Molecular weight 413.17
XLogP 8.23
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
BRD4770 is an analogue of the SAM (S-adenosyl methionine) mimetic, BIX-01338 [1-2]. SAM is a cofactor in the methylation reaction catalysed by histone lysine methyltransferases (HMTases or KMTs). BRD4770 reduces di- and tri- methylation levels of histone H3, most likely via inhibition of the KMT, EHMT2 (aka G9a or KMT1C), and induces cell senescence, but not apoptosis [2].