daminozide

Ligand id: 7025

Name: daminozide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 69.64
Molecular weight 160.08
XLogP -1.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Daminozide is a highly selective inhibitor of the KDM2/7 family of human JmjC histone demethylases [1]. This subfamily of demethylasaes uses 2-oxoglutarate (2OG) as a cosubstrate and includes KDM2A, 2B and 7A as well as PHF8. Daminozide binds within the 2OG binding site and chelates the iron ion located in this pocket, thus blocking enzyme activity .