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Compound class:
Peptide or derivative
Comment: C21 is a synthetic analogue of a histone H4 tail peptide sequence bearing a chloroacetamidine side group. This compound was developed as a protein arginine methyltransferase (PRMT) inhibitor. Full information describing the design and synthesis of C21 is available in Obianyo et al (2011) [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| No information available. |
Mechanism Of Action and Pharmacodynamic Effects  |
| PRMTs catalyze the transfer of a methyl group from S-adenosyl methionine (SAM) to the guanidinium nitrogens of arginine residues in proteins. C21 irreversibly inactivates PRMT1 [1]. |
