isosorbide dinitrate

Ligand id: 7051

Name: isosorbide dinitrate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 123.2
Molecular weight 236.03
XLogP 0.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat angina
Mechanism Of Action and Pharmacodynamic Effects
Isosorbide dinitrate is converted to nitric oxide (NO). This activates soluble guanylyl cyclase which in turn increases cGMP synthesis, leading to downstream release of calcium ions and finally relaxation of the smooth muscle cells and vasodilation.