isosorbide mononitrate

Ligand id: 7052

Name: isosorbide mononitrate

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View more information in the IUPHAR Pharmacology Education Project: isosorbide mononitrate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 91.06
Molecular weight 191.04
XLogP -0.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Isosorbide mononitrate is used to prevent angina chest pains.
Mechanism Of Action and Pharmacodynamic Effects
Nitrates reduce the workload of the heart by causing venous and arterial dilation. The pathway includes production of nitric oxide (NO), activation of guanylate cyclase, increased synthesis of cGMP, activation of kinase-dependent phosphorylation in the smooth muscle cells and eventual dephosphorylation of myosin light chains in the smooth muscle fibers. This sequence of events culminates in the release of calcium ions, which causes smooth muscle relaxation and vasodilation. See the DrugBank link for further details.