desogestrel

Ligand id: 7065

Name: desogestrel

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 20.23
Molecular weight 310.23
XLogP 5.49
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a component of combined oral contraceptive formulations. The 1992 US FDA approval for this compound is in combination with ethinyl estradiol. The Electronic Medicines Compendium (eMC) has records for the single component drug with marketing authorisation granted in 2012.
Mechanism Of Action and Pharmacodynamic Effects
Desogestrel is an agonist of the progesterone receptor. Artificial maintainence of high levels of circulating progesterone feeds back to reduce the frequency of gonadotrophin-releasing hormone (GnRH) pulses which blunts the pre-ovulatory lutenising hormone (LH) surge, and the ovaries cease cyclic ovulation.
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