Ligand id: 7070

Name: dyphylline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 98.9
Molecular weight 254.1
XLogP -2.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dyphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.
Mechanism Of Action and Pharmacodynamic Effects
CHEMBL report that the molecular targets of this drug are phosphodiesterases 3A and 4 (genes PDE3A, PDE4A, PDE4B, PDE4C and PDE4D) are listed in this database, in the Cyclic nucleotide turnover section. Drug-induced inhibition of phosphodiesterases causes increased cAMP levels, which results in relaxation of the bronchial smooth muscle, and antagonises adenosine receptors. See the DrugBank link for further details.
External links