fluocinonide

Ligand id: 7078

Name: fluocinonide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.13
Molecular weight 494.21
XLogP 1.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fluocinonide is the active component in creams used to treat inflammatory and pruritic skin conditions.
Mechanism Of Action and Pharmacodynamic Effects
As an agonist of the glucocorticoid receptor, fluocinonide modulates expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.