Ligand id: 7090

Name: nelarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 132.85
Molecular weight 297.11
XLogP -1.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), especially in patients with relapsed disease or who are unresponsive to other chemotherapies.
Mechanism Of Action and Pharmacodynamic Effects
The incorporation of the active compound metabolised from nelarabine, inhibits DNA synthesis and causes cell death.
External links