norgestimate

Ligand id: 7091

Name: norgestimate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 58.89
Molecular weight 369.23
XLogP 4.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Norgestimate is approved along with ethinyl estradiol in combined oral contraceptive formulations.
Mechanism Of Action and Pharmacodynamic Effects
Artificial maintainence of high levels of circulating progestin feeds back to reduce the frequency of gonadotrophin-releasing hormone (GnRH) pulses which blunts the pre-ovulatory lutenising hormone (LH) surge, and the ovaries cease cyclic ovulation.