ursodeoxycholic acid

Ligand id: 7104

Name: ursodeoxycholic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 77.76
Molecular weight 392.29
XLogP 6.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat primary biliary cirrhosis [2] and biliary stasis in pregnant women. Also used to dissolve cholesterol gallstones in patients as an alternative to cholecystectomy. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Reduces cholesterol absorption by reducing the rate at which the intestine absorbs cholesterol molecules. See the DrugBank link for further details.
External links