Ligand id: 7105

Name: vinorelbine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 133.87
Molecular weight 778.39
XLogP 3.9
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat breast cancer, non-small cell lung cancer and rhabdomyosarcoma. This drug may be used alone or in combination with other medications.
Mechanism Of Action and Pharmacodynamic Effects
Vinorelbine is a semi-synthetic vinca alkaloid that inhibits tubulin [1] and interferes with normal microtubule function. This causes mitotic arrest and cell death.
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