anagrelide

Ligand id: 7114

Name: anagrelide

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: anagrelide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 48.19
Molecular weight 255
XLogP 1.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat essential thrombocythaemia.
Mechanism Of Action and Pharmacodynamic Effects
Reduces the disease associated high platelet count by inhibiting the maturation of platelets from megakaryocytes, potentially via the inhibition of phosphodiesterases [1].
External links