bendroflumethiazide

Ligand id: 7122

Name: bendroflumethiazide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 135.12
Molecular weight 421.04
XLogP 3.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to reduce oedema and hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Believed to inhibit the renal Na-Cl symporter SLC12A3 (thiazide-sensitive sodium-chloride cotransporter), causing increased water excretion via the urinary system.
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