Ligand id: 7135

Name: bupropion

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View more information in the IUPHAR Pharmacology Education Project: bupropion

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 29.1
Molecular weight 239.11
XLogP 3.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bupropion is used to aid smoking cessation (in combination with motivational support) in nicotine-dependent patients. Some countries authorise use for additional indications eg major depressive disorder in the US and Canada and seasonal affective disorder in Canada.
In September 2014 the US FDA approved Contrave® (bupropion and naloxone), a fixed-mixture medication, to be used in conjunction with reduced-calorie intake and physical activity, as a treatment for chronic weight management.
Mechanism Of Action and Pharmacodynamic Effects
The mode of action of bupirion in smoking cessation is not completely understood., but appears to involve inhibition of serotonin and dopamine reuptake.
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