Ligand id: 7138

Name: butalbital

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 82.25
Molecular weight 224.12
XLogP 2.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat pain and headache, often in a combined formulation containing acetaminophen or aspirin. However, there is no information regarding approval for clinical use of this drug as a single agent, on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Binds to the CNS GABAA Cl- channel, increasing inhibitory GABAergic tone.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.