clobazam

Ligand id: 7149

Name: clobazam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 40.62
Molecular weight 300.07
XLogP 3.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Indicated for the short-term relief of severe, disabling anxiety and may be used as adjunctive therapy in epilepsy.
Mechanism Of Action and Pharmacodynamic Effects
Clobazol acts as an anxiolytic by allosterically modulating GABAA chloride channels in the CNS, increasing inhibitory GABAergic tone and causing neuro-inhibition of the cortical and limbic systems.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
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