Ligand id: 7151

Name: cyclizine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 6.48
Molecular weight 266.18
XLogP 5.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat the symptoms of motion sickness, and nausea experienced post-operatively, or associated with radiotherapy.
Mechanism Of Action and Pharmacodynamic Effects
Cyclizine blocks the action of endogenous histamine at the histamine H1 receptor in the vomiting center of the medullary brain..
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