dibucaine

Ligand id: 7159

Name: dibucaine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 57.95
Molecular weight 343.23
XLogP 4.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to produce local or regional anaesthesia (eg percutaneous injection, lumbar and epidural procedures and topical application). This drug is approved as dibucaine (USAN) in the US, for topical use, although no approval date is available. The Electronic Medicines Compendium (eMC) also only has records for topical medications containing the ingredient cinchocaine (INN) in combination products with anti-inflammatory components.
Mechanism Of Action and Pharmacodynamic Effects
This drug inhibits sodium influx through neuronal voltage gated sodium channels. This prevents membrane depolarisation and subsequently blocks initiation and propagation of nerve impulses.
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